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Omeprazole Identifier:
The route of administration ORAL
The active ingredient list OMEPRAZOLE
The pharmacological class category Proton Pump Inhibitor [EPC],Proton Pump Inhibitors [MoA]

National Drug Code (NDC) The trade name The active ingredient(s) The dosage form The start date Name of Company Strength Number and Unit
0113-0915 Good Sense Omeprazole Omeprazole TABLET, DELAYED RELEASE 20080228 L. Perrigo Company 20mg/1
0179-1804 Omeprazole omeprazole CAPSULE, DELAYED RELEASE 20060602 KAISER FOUNDATION HOSPITALS 10mg/1
0186-0510 VIMOVO naproxen and esomeprazole magnesium TABLET, DELAYED RELEASE 20100706 AstraZeneca LP 20; 375mg/1; mg/1

Full Omeprazole Identification


Omeprazole is indicated for the treatment of gastroesophageal reflux disease.
Prescription omeprazole is indicated alone or with other prescriptions to treat ulcers (sores in the lining of the stomach or small intestine), gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and injury of the esophagus (tube that connects the mouth and stomach), and erosive esophagitis (swelling and wearing away of the lining of the esophagus). Omeprazole delayed-release capsules are also used to treat conditions in which the stomach produces too much acid. Omeprazole delayed-release capsules are also used in combination with other prescriptions to eliminate H. pylori(a bacteria that causes ulcers) and possibly prevent new ulcers from developing in patients who have or have had ulcers of the small intestine. Omeprazole powder for suspension (to be mixed with water) is also used to prevent bleeding from the esophagus, stomach, or the top of the small intestine in people who have life-threatening illnesses. Nonprescription omeprazole is indicated to treat frequent heartburn (heartburn that occurs at least 2 days a week). Omeprazole is in a class of prescriptions called proton-pump inhibitors. It works by decreasing the amount of acid made in the stomach.

A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and zollinger-ellison syndrome. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-exchanging ATPase) in the proton pump of gastric parietal cells.


Omeprazole delayed-release capsules are contraindicated in patients with known hypersensitivity to any component of the formulation.


Omeprazole comes as a delayed-release capsule (Omeprazole), a nonprescription delayed-release tablet (Omeprazole OTC), a powder for suspension (Zegerid) , and a regular capsule (Zegerid). The powder and regular capsule also contain sodium bicarbonate, a prescription that decreases the amount of acid in the stomach and helps omeprazole to work quickly. The delayed-release capsules are usually taken once a day before a meal, but may be taken twice a day when used with other prescriptions to eliminate H. pylori or up to three times a day when used to treat conditions in which the stomach produces too much acid. The capsules are usually taken once a day in the morning on an empty stomach one hour before a meal. The powder is usually taken once a day on an empty stomach one hour before a meal either in the morning or at bedtime. The nonprescription delayed-release tablets are usually taken once a day in the morning before eating. The nonprescription tablets should be taken for 14 days in a row, and additional 14-day treatments may be repeated once every 4 months if needed. To help you remember to take omeprazole, take it at around the same time(s) every day. Follow the directions on your prescription label or the package label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take omeprazole exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than indicated by your doctor or stated on the package.

Swallow the regular omeprazole capsules with water. Do not swallow the capsules with any other liquid.

Swallow the delayed-release omeprazole capsules, the regular capsules, and the nonprescription delayed-release tablets whole; do not split, open, chew or crush them. Do not crush the nonprescription delayed-release tablets in food and do not open the regular capsules and mix the contents with food.

If you have difficulty swallowing the delayed-release capsules, you may add the contents of a delayed-release capsule to applesauce. Place one tablespoon of soft, cool applesauce in an empty bowl. Open the delayed-release capsule and carefully empty all the pellets inside the capsule onto the applesauce. Mix the pellets with the applesauce and swallow the mixture immediately with a glass of cool water. Do not chew or crush the pellets. Do not store the applesauce/pellet mixture for future use.

If you are taking the powder, you must mix it with water before use. Place 1-2 tablespoons of water into a small cup and add the contents of one powder packet. Mix well and drink the mixture immediately. Refill the cup with water and drink the water to be sure that you swallow all of the prescription. Do not mix the prescription with any other liquid or with food.

If you are taking the powder or the regular capsules, be sure that you are taking the strength and the number of capsules or powder packets that your doctor indicated. If you were told to take one 40-mg capsule or powder packet, do not take two 20-mg capsules or powder packets instead. They do not contain the same amount of prescription as one 40-mg capsule or packet.Ask your doctor or pharmacist if you have any questions about how many capsules or packets you should take.

Do not take nonprescription omeprazole for immediate relief of heartburn symptoms. It may take 1-4 days for you to feel the full benefit of the prescription. Call your doctor if your symptoms get worse or do not improve after 14 days or if your symptoms return sooner than 4 months after you finish your treatment Do not take nonprescription omeprazole for longer than 14 days or more often than once every 4 months without talking to your doctor.

Your doctor may prescribe omeprazole for 10-14 days to eliminate H. pylori or for 4-8 weeks or longer to treat other conditions.

Omeprazole is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis, and H. pylori eradication to reduce the risk of duodenal ulcer recurrence. Omeprazole belongs to a new class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2 histamine antagonistic properties, but that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, omeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.

Side Effects

Omeprazole side effects that you should report to your health care professional or doctor as soon as possible:
- back pain;
- blurred vision;
- burning or tingling of the lips, tongue, hands, or feet;
- confusion;
- constipation;
- cough;
- diarrhea;
- difficulty breathing or swallowing;
- dizziness;
- drowsiness;
- dry mouth;
- fast or pounding heartbeat;
- flushing (feeling of warmth);
- headache;
- hives;
- hoarseness;
- itching;
- muscle spasms, tightening, aching, or cramping;
- nausea;
- rash;
- seizures;
- stomach pain;
- sweating;
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs;
- vomiting;
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